Sankalp Journal of Multidisciplinary Studies (SJMS), Volume : 1 Issue: 1, September- October 2021, Pp. 1-9 ACTIVE CONSTITUENTS ENHANCEMENT VIA NANOTECHNOLOGY IN NANOPARTICLE Z. OFFICINALE RHIZOME Norhidayah A, Noriham A, Rusop M.D, Faller E.M 1Faculty of Hotel and Tourism Management, Universiti Teknologi MARA Selangor, Puncak Alam Campus Malaysia 2Faculty of Applied Sciences, Universiti Teknologi MARA Shah Alam, Malaysia 3Nano-SciTech Institute, Universiti Teknologi MARA Shah Alam, Malaysia 4Faculty of Pharmacy, San Pedro College, Davao City, Philippines Abstract— Z. Officinale variety Bentong is the high-quality Z. officinale due to the presence of Z. officinale and flavonoid active compound which contribute to its functional properties. However, the active compounds were found to be poorly released in its larger particle which affects its functional property. Nanotechnology is a technology newly useful in the food handling and bioprocess industry through the development of materials in the nanoscale and proved to improve the functional properties of provisions tested. Hence, this study was initiated to investigate the effect of nanotechnology on the flavonoid profile of nanoparticle Z. officinale (NP) compared to its fine (FP) and coarse particle (CP). Nanotechnology has increases 67.59% of epicathecin, rutin (86.58%), myricetin (53.11%) and 76.63% of luteolin, almost 100% of kaempferol and quercetin but cause depletion of naringenin by 5.45% in NP. Nanotechnology has revealed the ability to upsurge the release of active complexes and cause a decrease in certain active compounds which may improve herbal purposeful possessions. Keywords— Flavonoid; Z. Officinale Nanotechnology, Z. Officinale.